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Genetic diversity and population structure of indigenous chicken breeds in South China

Xunhe HUANG,Jinfeng ZHANG,Danlin HE,Xiquan ZHANG,Fusheng ZHONG,Weina LI,Qingmei ZHENG,Jiebo CHEN,Bingwang DU

《农业科学与工程前沿（英文）》 2016年 第3卷 第2期   页码 97-101 doi: 10.15302/J-FASE-2016102

摘要： A total of 587 individuals from 12 indigenous chicken breeds from South China and two commercial breeds were genotyped for 26 microsatellites to investigate the genetic diversity and population structure. All microsatellites were found to be polymorphic. The number of alleles per locus ranged from 5 to 36, with an average of 12.10 ± 7.00 (SE). All breeds, except White Recessive Rock, had high allelic polymorphism (>0.5). Higher genetic diversity was revealed in the indigenous chicken breeds rather than in the commercial breeds. Potential introgression from the commercial breeds into the indigenous chickens was also detected. The population structure of these indigenous chicken breeds could be explained by their geographical distribution, which suggested the presence of independent history of breed formation. Data generated in this study will provide valuable information to the conservation for indigenous chicken breeds in future.

关键词： microsatellites     genetic diversity     population structure     indigenous chicken     South China     conservation    

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Genetic variability of Appaloosa horses: a study of a closed breeding population from Argentina

Claudia Malena CORBI-BOTTO,Sebastian Andres SADABA,Elina Ines FRANCISCO,Paula Belen KALEMKERIAN,Juan Pedro LIRON,Egle Etel VILLEGAS-CASTAGNASSO,Guillermo GIOVAMBATTISTA,Pilar PERAL-GARCIA,Silvina DIAZ

《农业科学与工程前沿（英文）》 2014年 第1卷 第3期   页码 175-178 doi: 10.15302/J-FASE-2014019

摘要： The genetic diversity and structure of 72 Appaloosa horses belonging to a closed breeding population from an ecological reserve in Buenos Aires, Argentina, was investigated using eight microsatellite markers from the International Society for Animal Genetics panel. Our data showed that this Appaloosa horse population had an elevated degree of genetic diversity (He= 0.746) and did not present a significant increase of homozygous individuals ( ~0). However, the short tandem repeats, AHT5, ASB2, HTG10 and VHL20, were not in Hardy–Weinberg equilibrium ( -value<0.05). Genetic relationships between this population and other well known horse breeds showed that Appaloosa horses from Argentina could have had their origin in the horses of the Nez Perce’s people in Idaho while other Appaloosa horses may have had influences from Andalusian and Lusitano breeds. This closed breeding population conserves an important degree of Appaloosa genetic diversity and notwithstanding its particular breeding characteristics, represents a valuable genetic resource for conservation.

关键词： horse     genetic diversity     microsatellite     Appaloosa     population structure     conservation    

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Simulation of bubble column reactors using CFD coupled with a population balance model

Tiefeng WANG

《化学科学与工程前沿（英文）》 2011年 第5卷 第2期   页码 162-172 doi: 10.1007/s11705-009-0267-5

摘要： Bubble columns are widely used in chemical and biochemical processes due to their excellent mass and heat transfer characteristics and simple construction. However, their fundamental hydrodynamic behaviors, which are essential for reactor scale-up and design, are still not fully understood. To develop design tools for engineering purposes, much research has been carried out in the area of computational fluid dynamics (CFD) modeling and simulation of gas-liquid flows. Due to the importance of the bubble behavior, the bubble size distribution must be considered in the CFD models. The population balance model (PBM) is an effective approach to predict the bubble size distribution, and great efforts have been made in recent years to couple the PBM into CFD simulations. This article gives a selective review of the modeling and simulation of bubble column reactors using CFD coupled with PBM. Bubble breakup and coalescence models due to different mechanisms are discussed. It is shown that the CFD-PBM coupled model with proper bubble breakup and coalescence models and interphase force formulations has the ability of predicting the complex hydrodynamics in different flow regimes and, thus, provides a unified description of both the homogeneous and heterogeneous regimes. Further study is needed to improve the models of bubble coalescence and breakup, turbulence modification in high gas holdup, and interphase forces of bubble swarms.

关键词： bubble column     computational fluid dynamics     bubble breakup and coalescence     population balance model     bubble size distribution    

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Effects of hydraulic retention time on nitrification activities and population dynamics of a conventional

Hongyan LI, Yu ZHANG, Min YANG, Yoichi KAMAGATA

《环境科学与工程前沿（英文）》 2013年 第7卷 第1期   页码 43-48 doi: 10.1007/s11783-012-0397-8

摘要： The effects of hydraulic retention time (HRT) on the nitrification activities and population dynamics of a conventional activated sludge system fed with synthetic inorganic wastewater were investigated over a period of 260 days. When the HRT was gradually decreased from 30 to 5 h, the specific ammonium-oxidizing rates (SAOR) varied between 0.32 and 0.45 kg (kg mixed liquor suspended solids (MLSS)·d) , and the specific nitrate-forming rates (SNFR) increased from 0.11 to 0.50 kg (kg MLSS·d) , showing that the decrease in HRT led to a significant increase in the nitrite oxidation activity. According to fluorescence in situ hybridization (FISH) analysis results, the proportion of ammonia-oxidizing bacteria (AOBs) among the total bacteria decreased from 33% to 15% with the decrease in HRT, whereas the fraction of nitrite-oxidizing bacteria (NOBs), particularly the fast-growing sp., increased significantly (from 4% to 15% for NOBs and from 1.5% to 10.6% for sp.) with the decrease in HRT, which was in accordance with the changes in SNFR. A short HRT favored the relative growth of NOBs, particularly the fast-growing sp., in the conventional activated sludge system.

关键词： ammonia-oxidizing bacteria     hydraulic retention time     nitrification activity     nitrite-oxidizing bacteria     population dynamics    

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Socialized care services for the aged population: System construction and support measures

《工程管理前沿（英文）》 2023年 第10卷 第2期   页码 339-353 doi: 10.1007/s42524-022-0208-2

摘要： Given the aging society, an increase in social demand, information- and communication technology-driven culture, and government policy support emerges to enable the development of the socialized care services system for the aged (SCSSA). The development of the SCSSA would be a significant step toward addressing China’s aging population. However, the construction of the SCSSA challenges the theories and methods of traditional elderly care service system construction. Specifically, the implementation path for such elderly care service policies is unclear, the necessary technological support is insufficient, and the mechanism for integrating intelligent information technology remains underexplored. Thus, this paper focuses on the needs of the elderly, grounded in the context of the changing elderly care service policies in China, and proposes a research paradigm that integrates system construction and support measure embedding. We then construct the original SCSSA, which includes “material + spirit + medical treatment + healthcare” and propose a method of optimization and iteration. Finally, we build the research framework of systematic support measures from the perspectives of policy reconstruction, institutional embeddedness, and technical support. Our work provides theoretical support and practical guidance for the construction and dynamic optimization of the SCSSA, thus making a significant contribution that will help China effectively cope with its aging society.

关键词： socialized     care service for the elderly     system construction     support measure    

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Identification of molecular markers linked to rice bacterial blight resistance genes from

Jing WANG,Chen CHENG,Yanru ZHOU,Yong YANG,Qiong MEI,Junmin LI,Ye CHENG,Chengqi YAN,Jianping CHEN

《农业科学与工程前沿（英文）》 2015年 第2卷 第3期   页码 260-265 doi: 10.15302/J-FASE-2015070

摘要： Y73 is a progeny of asymmetric somatic hybridization between cv. Dalixiang and the wild rice species . Inoculation with a range of strains of pv. showed that Y73 had inherited a high level of resistance to rice bacterial blight (BB) from its wild parent. An F population of 7125 individuals was constructed from the cross between Y73 and a BB-susceptible cultivar IR24. After testing 615 SSR and STS markers covering the 12 rice chromosomes, 186 markers were selected that showed polymorphism between Y73 and IR24. Molecular markers linked to the BB resistance genes in Y73 were scanned using the F population and the polymorphic markers. The SSR marker RM128 on chromosome 1, the STS marker R03D159 on chromosome 3 and the STS marker R05D104 on chromosome 5 were found to be linked to the rice BB resistance genes in Y73.

关键词： Oryza meyeriana     bacterial blight resistance gene     genetic population     linkage molecular marker    

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Obesity and overweight prevalence and its association with undiagnosed hypertension in Shanghai population, China: a cross-sectional population-based survey

null

《医学前沿（英文）》 2012年 第6卷 第3期   页码 322-328 doi: 10.1007/s11684-012-0204-8

摘要：

The aim of this study was to determine the prevalence of overweight and obese subjects in the Shanghai population of China and its association with undiagnosed hypertension, by taking age, gender and place of residence (urban or suburban) into account. A cross-sectional population-based survey was conducted in 2007. The sample included 13 359 participants aged 15–69 years. Weight, height, and blood pressure were recorded, and information about gender, age and place of residence was obtained. Overweight and obesity prevalence were calculated by the body mass index (BMI) definition recommended by Working Group on Obesity in China (normal weight, 18.5–23.9 kg/m2; overweight, 24–27.9 kg/m2; obesity,≥28 kg/m2). Undiagnosed hypertension was defined by China criteria in accord with that of WHO-ISH (subjects with systolic pressure≥140 mmHg, and/or diastolic pressure≥90 mmHg). Multiple logistic regression analyses were used to assess the association of overweight or obesity with undiagnosed hypertension by adjusting for age, gender and place of residence. The overall overweight, obesity, and undiagnosed hypertension prevalence were 27.6% (95% CI: 26.8–28.4), 6.6% (95% CI: 6.2–7.0), and 15.5% (95% CI: 14.9–16.1), respectively. Compared to normal weight subjects, the odds ratios (OR) for subjects who were overweight and had hypertension was 2.33 (95% CI: 2.10–2.59); that for obesity and hypertension was 4.27 (95% CI: 3.66–4.99). These data suggest that overweight and obesity prevalence and their association with undiagnosed hypertension are high in our study population.

关键词： overweight     obesity     undiagnosed hypertension     prevalence     association    

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Prognostic analysis of chronic myeloid leukemia in Chinese population in an imatinib era

null

《医学前沿（英文）》 2012年 第6卷 第2期   页码 204-211 doi: 10.1007/s11684-012-0202-x

摘要：

We evaluated the outcomes of chronic myeloid leukemia (CML) patients in three clinical phases, namely, chronic (CP), accelerated (AP), and blast (BP) phases, receiving imatinib treatment. The single-institution treatment experiences of Chinese patients with CML were presented. A total of 275 CML patients (CP, 210; AP, 24; and BP, 41) who received imatinib between February 2001 and April 2008 were enrolled in this study. We evaluated the responses (hematologic, cytogenetic, and molecular), overall survival (OS), treatment event-free survival (EFS), and prognostic factors of outcome. At the cut-off point, the complete cytogenetic response (CCyR) and complete molecular response rates of patients in the CP were 84.7% and 61.9%, respectively, which were significantly higher than those of patients in the AP (50% and 29.1%, respectively, both P<0.001) and BP (24.3% and 9.7%, respectively, both P<0.001). The estimated five-year OS and five-year EFS rates were 93.2% and 86.4% for CP patients, as well as 64.5% and 50.9% for AP patients, which were significantly higher than those for BP patients (P<0.001). In CP patients, univariate analysis revealed that early treatment with imatinib, achieving CCyR within 12 months, additional cytogenetic abnormalities, and kinase domain mutations were associated with the treatment outcome. More patients are needed to carry out multivariate analysis.

关键词： imatinib     chronic myeloid leukemia     complete cytogenetic response    

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Projections of heat-related excess mortality in China due to climate change, population and aging

《环境科学与工程前沿（英文）》 2023年 第17卷 第11期 doi: 10.1007/s11783-023-1732-y

摘要：

● Four scenarios were used to project heat-related excess mortality in China.

关键词： Heat-related excess mortality     LMDI     Aging     YLL     VSLY    

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Are the SNPs of NKX2-1 associated with papillary thyroid carcinoma in the Han population of Northern

null

《医学前沿（英文）》 2014年 第8卷 第1期   页码 113-117 doi: 10.1007/s11684-014-0310-x

摘要：

Papillary thyroid carcinoma (PTC) is one of the most common tumors of the thyroid gland. The common risk factors of PTC include ionizing radiation, positive family history, and thyroid nodular disease. PTC was identified in Europeans by conducting a genome-wide association study, and a strong association signal with PTC was observed in rs944289 and NKX2-1 (located at the 14q13.3 locus), which was probably the genetic risk factor of PTC. This study aimed to examine the association of this gene with PTC in Chinese. A total of 354 patients with PTC and 360 healthy control subjects from the Han population of Northern China were recruited in the study. These individuals were genotyped to determine rs12589672, rs12894724, rs2076751, and rs944289. The association of rs944289 with PTC was obtained (C vs. T, P=0.027, OR=1.264, 95% CI=1.026-1.557; and C/C-C/T vs. T/T, P=0.034, OR=1.474, 95% CI=1.028-2.112). Conducting a subgroup analysis, we found a marginal difference in the allele frequency distribution of rs944289 (adjusted P=0.062) between the patients with PTC and multi-nodular goiter and the control subjects. We also observed an interaction (P=0.029; OR=2.578, 95% CI=1.104-6.023) between rs944289 and diabetes in patients with PTC. In conclusion, rs944289 was associated with an increased risk of PTC in the Han population of Northern China, but no clear association was observed in either of the tag single nucleotide polymorphisms of NKX2-1.

关键词： NKX2-1     papillary thyroid carcinoma     the Han population of Northern China     association    

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Status of hyperhomocysteinemia in China: results from the China Stroke High-risk Population Screening

《医学前沿（英文）》 2021年 第15卷 第6期   页码 903-912 doi: 10.1007/s11684-021-0871-4

摘要： A nationwide survey was conducted from October 2018 to September 2019 to assess the prevalence of hyperhomocysteinemia (Hhcy) and its influencing factors in China. A standardized questionnaire was used to collect information. Hhcy was defined as the level of serum homocysteine (HCY) ≥15.0 µmol/L. The H-type hypertension (HHYP) was defined as hypertension with an elevated serum HCY (≥15.0 µmol/L). Finally, 110 551 residents ≥40 years of age from 31 provinces in the mainland of China were included. Overall, the median serum HCY level was 10.9 µmol/L (interquartile range 7.9–15.1). A total of 28 633 participants (25.9%) were defined as Hhcy. The Hhcy prevalence ranged from 7.9% in Shanghai to 56.8% in Tianjin. The data showed that serum HCY levels were associated with age, male gender, cigarette smoking, hypertension, diabetes, ethnicity, endurance in exercise (inverse), and fruit and vegetable intake (inverse). In addition, 15 486 participants were defined as HHYP, and the rate was 14.0%. HHYP was an independent predictor of stroke with an adjusted odds ratio of 1.752 (95% CI 1.338–2.105). The geographical distribution pattern of the Hhcy epidemic reflects dynamic differences, and national strategies should be carried out to further improve the care of patients with Hhcy across China.

关键词： homocysteine     hyperhomocysteinemia     H-type hypertension     Chinese    

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Machine learning modeling identifies hypertrophic cardiomyopathy subtypes with genetic signature

《医学前沿（英文）》 2023年 第17卷 第4期   页码 768-780 doi: 10.1007/s11684-023-0982-1

摘要： Previous studies have revealed that patients with hypertrophic cardiomyopathy (HCM) exhibit differences in symptom severity and prognosis, indicating potential HCM subtypes among these patients. Here, 793 patients with HCM were recruited at an average follow-up of 32.78 ± 27.58 months to identify potential HCM subtypes by performing consensus clustering on the basis of their echocardiography features. Furthermore, we proposed a systematic method for illustrating the relationship between the phenotype and genotype of each HCM subtype by using machine learning modeling and interactome network detection techniques based on whole-exome sequencing data. Another independent cohort that consisted of 414 patients with HCM was recruited to replicate the findings. Consequently, two subtypes characterized by different clinical outcomes were identified in HCM. Patients with subtype 2 presented asymmetric septal hypertrophy associated with a stable course, while those with subtype 1 displayed left ventricular systolic dysfunction and aggressive progression. Machine learning modeling based on personal whole-exome data identified 46 genes with mutation burden that could accurately predict subtype propensities. Furthermore, the patients in another cohort predicted as subtype 1 by the 46-gene model presented increased left ventricular end-diastolic diameter and reduced left ventricular ejection fraction. By employing echocardiography and genetic screening for the 46 genes, HCM can be classified into two subtypes with distinct clinical outcomes.

关键词： machine learning methods     hypertrophic cardiomyopathy     genetic risk    

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Enhancing the efficiency of nitrogen removing bacterial population to a wide range of C:N ratio (1.5:

《环境科学与工程前沿（英文）》 2022年 第16卷 第8期 doi: 10.1007/s11783-022-1522-y

摘要：

• Simultaneous C & N removal in Methammox occurs at wide C:N ratio.

关键词： Methanogens     Biological Nitrogen Removal (BNR)     Simultaneous     Methammox     C:N ratio    

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Nitrifying population dynamics in a redox stratified membrane biofilm reactor (RSMBR) for treating ammonium-rich

Rongchang WANG, Xinmin ZHAN, Yalei ZHANG, Jianfu ZHAO

《环境科学与工程前沿（英文）》 2011年 第5卷 第1期   页码 48-56 doi: 10.1007/s11783-011-0305-7

摘要： Nitrogen removal performance and nitrifying population dynamics were investigated in a redox stratified membrane biofilm reactor (RSMBR) under oxygen limited condition to treat ammonium-rich wastewater. When the loading rate increased from 11.1±1.0 to , the nitrogen removal in the RSMBR system increased from 18.0±9.6 mgN·d to 128.9±61.7 mgN·d . Shortcut nitrogen removal was achieved with nitrite accumulation of about . Confocal micrographs showed the stratified distributions of nitrifiers and denitrifiers in the membrane aerated biofilms (MABs) at day 120, i.e., ammonia and nitrite oxidizing bacteria (AOB and NOB) were dominant in the region adjacent to the membrane, while heterotrophic bacteria propagated at the top of the biofilm. Real-time qPCR results showed that the abundance of gene was two orders of magnitude higher than the abundance of gene in the MABs. However, the gene was always detected during the operation time, which indicates the difficulty of complete washout of NOB in MABs. The growth of heterotrophic bacteria compromised the dominance of nitrifiers in biofilm communities, but it enhanced the denitrification performance of the RSMBR system. Applying a high ammonia loading together with oxygen limitation was found to be an effective way to start nitrite accumulation in MABs, but other approaches were needed to sustain or improve the extent of nitritation in nitrogen conversion in MABs.

关键词： ammonium-rich wastewater     membrane biofilm reactor     nitrification     redox stratification     shortcut nitrogen removal    

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Interplay between diet and genetic susceptibility in obesity and related traits

Tiange Wang, Min Xu, Yufang Bi, Guang Ning

《医学前沿（英文）》 2018年 第12卷 第6期   页码 601-607 doi: 10.1007/s11684-018-0648-6

摘要：

The incidence of obesity has been rapidly increasing, and this condition has become a major public health threat. A substantial shift in environmental factors and lifestyle, such as unhealthy diet, is among the major driving forces of the global obesity pandemic. Longitudinal studies and randomized intervention trials have shown that genetic susceptibility to obesity may interact with dietary factors in relation to the body mass index and risk of obesity. This review summarized data from recent longitudinal studies and intervention studies on variations and diets and discussed the challenges and future prospects related to this area and public health implications.

关键词： diet     genetic susceptibility     obesity     interaction    

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标题 作者 时间 类型 操作

Genetic diversity and population structure of indigenous chicken breeds in South China

Xunhe HUANG,Jinfeng ZHANG,Danlin HE,Xiquan ZHANG,Fusheng ZHONG,Weina LI,Qingmei ZHENG,Jiebo CHEN,Bingwang DU

期刊论文

Genetic variability of Appaloosa horses: a study of a closed breeding population from Argentina

Claudia Malena CORBI-BOTTO,Sebastian Andres SADABA,Elina Ines FRANCISCO,Paula Belen KALEMKERIAN,Juan Pedro LIRON,Egle Etel VILLEGAS-CASTAGNASSO,Guillermo GIOVAMBATTISTA,Pilar PERAL-GARCIA,Silvina DIAZ

期刊论文

Simulation of bubble column reactors using CFD coupled with a population balance model

Tiefeng WANG

期刊论文

Effects of hydraulic retention time on nitrification activities and population dynamics of a conventional

Hongyan LI, Yu ZHANG, Min YANG, Yoichi KAMAGATA

期刊论文

Socialized care services for the aged population: System construction and support measures

期刊论文

Identification of molecular markers linked to rice bacterial blight resistance genes from

Jing WANG,Chen CHENG,Yanru ZHOU,Yong YANG,Qiong MEI,Junmin LI,Ye CHENG,Chengqi YAN,Jianping CHEN

期刊论文

Obesity and overweight prevalence and its association with undiagnosed hypertension in Shanghai population, China: a cross-sectional population-based survey

null

期刊论文

Prognostic analysis of chronic myeloid leukemia in Chinese population in an imatinib era

null

期刊论文

Projections of heat-related excess mortality in China due to climate change, population and aging

期刊论文

Are the SNPs of NKX2-1 associated with papillary thyroid carcinoma in the Han population of Northern

null

期刊论文

Status of hyperhomocysteinemia in China: results from the China Stroke High-risk Population Screening

期刊论文

Machine learning modeling identifies hypertrophic cardiomyopathy subtypes with genetic signature

期刊论文

Enhancing the efficiency of nitrogen removing bacterial population to a wide range of C:N ratio (1.5:

期刊论文

Nitrifying population dynamics in a redox stratified membrane biofilm reactor (RSMBR) for treating ammonium-rich

Rongchang WANG, Xinmin ZHAN, Yalei ZHANG, Jianfu ZHAO

期刊论文

Interplay between diet and genetic susceptibility in obesity and related traits

Tiange Wang, Min Xu, Yufang Bi, Guang Ning

期刊论文